Physiological and Anatomical Circuitry between Agouti-Related Protein and Leptin Signaling*

Proopiomelanocortin, agouti-related protein, and leptin in human cerebrospinal fluid: correlations with body weight and adiposity.

Leptin and its neuronal targets, which produce proopiomelanocortin (POMC) and agouti-related protein (AgRP), regulate energy balance. This study characterized leptin, POMC, and AgRP in the cerebrospinal fluid (CSF) of 47 healthy human subjects, 23 lean and 24 overweight/obese (OW/OB), as related to BMI, adiposity, plasma leptin, soluble leptin receptor (s-OB-R), and insulin. POMC was measured s...

Title : Proopiomelanocortin , Agouti - Related Protein and Leptin in Human Cerebrospinal 1 Fluid : Correlations with Body

Department of Medicine, Columbia University College of Physicians & Surgeons, New York, N.Y. 7 Faculties of Life Sciences and Medical and Human Sciences, University of Manchester, Manchester, UK 8 Department of Pediatrics, Columbia University College of Physicians & Surgeons, New York, N.Y. 9 Department of Anesthesiology, Columbia University College of Physicians & Surgeons, New York, 10 N.Y. 1...

Hypothalamic agouti-related protein messenger ribonucleic acid is inhibited by leptin and stimulated by fasting.

Agouti-related protein (AGRP) is a homologue of the agouti gene product and, when overexpressed, promotes obesity. Like neuropeptide Y (NPY) messenger RNA (mRNA), AGRP mRNA is produced in the hypothalamic arcuate nucleus and is elevated in leptin-deficient ob/ob and leptin-resistant db/db mice. These data suggest that AGRP mRNA might be affected by leptin and nutritional status in parallel with...

the relationship between field-related cognitive styles and global reading comprehension of hypertext

this study investigates the relationship between field-related cognitive styles and global reading comprehension of hypertext. technically, field dependency is prevailing dominance of field on perception of parts, while global comprehension is skim-like reading to grasp the general content. in this research project, 60 senior and junior students of arak university majoring in english literature...

Reply to Braasch and Postlethwait: Evolutionary origin of the teleost A2 agouti genes (agouti signaling protein 2 and agouti-related protein 2) remains unclear.